Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BRAF(V600E)–Driven Lung Tumors

Autophagic elimination of defective mitochondria suppresses oxidative stress and preserves mitochondrial function. Here, the essential autophagy gene Atg7 was deleted in a mouse model of BRAF(V600E)-induced lung cancer in the presence or absence of the tumor suppressor TRP53. Atg7 deletion initially...

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Bibliographic Details
Main Authors: Strohecker, Anne M., Guo, Jessie Yanxiang, Karsli-Uzunbas, Gizem, Price, Sandy M., Chen, Guanghua Jim, Mathew, Robin, McMahon, Martin, White, Eileen
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823822/
https://ncbi.nlm.nih.gov/pubmed/23965987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0397
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