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Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BRAF(V600E)–Driven Lung Tumors
Autophagic elimination of defective mitochondria suppresses oxidative stress and preserves mitochondrial function. Here, the essential autophagy gene Atg7 was deleted in a mouse model of BRAF(V600E)-induced lung cancer in the presence or absence of the tumor suppressor TRP53. Atg7 deletion initially...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3823822/ https://ncbi.nlm.nih.gov/pubmed/23965987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0397 |
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