Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

Macroautophagy (autophagy hereafter) degrades and recycles proteins and organelles to support metabolism and survival in starvation. Oncogenic Ras up-regulates autophagy, and Ras-transformed cell lines require autophagy for mitochondrial function, stress survival, and engrafted tumor growth. Here, t...

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Detalhes bibliográficos
Main Authors: Guo, Jessie Yanxiang, Karsli-Uzunbas, Gizem, Mathew, Robin, Aisner, Seena C., Kamphorst, Jurre J., Strohecker, Anne M., Chen, Guanghua, Price, Sandy, Lu, Wenyun, Teng, Xin, Snyder, Eric, Santanam, Urmila, DiPaola, Robert S., Jacks, Tyler, Rabinowitz, Joshua D., White, Eileen
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713426/
https://ncbi.nlm.nih.gov/pubmed/23824538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.219642.113
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