Haploinsufficiency of p18(INK4c) Sensitizes Mice to Carcinogen-Induced Tumorigenesis

The INK4 family of cyclin-dependent kinase (CDK) inhibitors negatively regulates cyclin D-dependent CDK4 and CDK6 and thereby retains the growth-suppressive function of Rb family proteins. Mutations in the CDK4 gene conferring INK4 resistance are associated with familial and sporadic melanoma in hum...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Bai, Feng, Pei, Xin-Hai, Godfrey, Virginia L., Xiong, Yue
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 2003
Sujets:	DNA Dynamics and Chromosome Structure
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC141153/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12556487/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.4.1269-1277.2003
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