Haploinsufficiency of p18(INK4c) Sensitizes Mice to Carcinogen-Induced Tumorigenesis
The INK4 family of cyclin-dependent kinase (CDK) inhibitors negatively regulates cyclin D-dependent CDK4 and CDK6 and thereby retains the growth-suppressive function of Rb family proteins. Mutations in the CDK4 gene conferring INK4 resistance are associated with familial and sporadic melanoma in hum...
Zapisane w:
| Wydane w: | Mol Cell Biol |
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| Główni autorzy: | , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Taylor & Francis
2003
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC141153/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12556487/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.4.1269-1277.2003 |
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