Targeting the Cyclin E-Cdk-2 Complex Represses Lung Cancer Growth by Triggering Anaphase Catastrophe

PURPOSE: Cyclin-dependent kinases (Cdks) and their associated cyclins are targets for lung cancer therapy and chemoprevention given their frequent deregulation in lung carcinogenesis. This study uncovered previously unrecognized consequences of targeting the cyclin E-Cdk-2 complex in lung cancer. EX...

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Main Authors: Galimberti, Fabrizio, Thompson, Sarah L., Liu, Xi, Li, Hua, Memoli, Vincent, Green, Simon R., DiRenzo, James, Greninger, Patricia, Sharma, Sreenath V., Settleman, Jeff, Compton, Duane A., Dmitrovsky, Ethan
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805048/
https://ncbi.nlm.nih.gov/pubmed/20028770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2151
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