Targeting the Cyclin E-Cdk-2 Complex Represses Lung Cancer Growth by Triggering Anaphase Catastrophe

PURPOSE: Cyclin-dependent kinases (Cdks) and their associated cyclins are targets for lung cancer therapy and chemoprevention given their frequent deregulation in lung carcinogenesis. This study uncovered previously unrecognized consequences of targeting the cyclin E-Cdk-2 complex in lung cancer. EX...

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Detalhes bibliográficos
Main Authors: Galimberti, Fabrizio, Thompson, Sarah L., Liu, Xi, Li, Hua, Memoli, Vincent, Green, Simon R., DiRenzo, James, Greninger, Patricia, Sharma, Sreenath V., Settleman, Jeff, Compton, Duane A., Dmitrovsky, Ethan
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805048/
https://ncbi.nlm.nih.gov/pubmed/20028770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2151
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