Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown

Chromosomal instability (CIN) is a hallmark of solid tumor biology and is implicated in carcinogenesis. Preferentially eliminating malignant cells by targeting CIN and aneuploidy is an attractive anti-neoplastic strategy. We previously reported that CDK2 antagonism causes lung cancer cells to underg...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Hu, Shanhu, Lu, Yun, Orr, Bernardo, Godek, Kristina, Mustachio, Lisa Maria, Kawakami, Masanori, Sekula, David, Compton, Duane A., Freemantle, Sarah, Dmitrovsky, Ethan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636444/
https://ncbi.nlm.nih.gov/pubmed/26304236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0443
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