Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer

Background: The first generation CDK2/7/9 inhibitor seliciclib (CYC202) causes multipolar anaphase and apoptosis in lung cancer cells with supernumerary centrosomes (known as anaphase catastrophe). We investigated a new and potent CDK2/9 inhibitor, CCT68127 (Cyclacel). Methods: CCT68127 was studied...

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Publicado no:J Natl Cancer Inst
Main Authors: Kawakami, Masanori, Mustachio, Lisa Maria, Rodriguez-Canales, Jaime, Mino, Barbara, Roszik, Jason, Tong, Pan, Wang, Jing, Lee, J. Jack, Myung, Ja Hye, Heymach, John V., Johnson, Faye M., Hong, Seungpyo, Zheng, Lin, Hu, Shanhu, Villalobos, Pamela Andrea, Behrens, Carmen, Wistuba, Ignacio, Freemantle, Sarah, Liu, Xi, Dmitrovsky, Ethan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6059250/
https://ncbi.nlm.nih.gov/pubmed/28376145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djw297
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