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Engaging Anaphase Catastrophe Mechanisms to Eradicate Aneuploid Cancers

Cancer cells often have supernumerary centrosomes that promote genomic instability, a pathognomonic feature of cancer. During mitosis, cancer cells with supernumerary centrosomes undergo bipolar cell division by clustering centrosomes into two poles. When supernumerary centrosome clustering is antag...

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Foilsithe in:Mol Cancer Ther
Main Authors: Kawakami, Masanori, Mustachio, Lisa Maria, Liu, Xi, Dmitrovsky, Ethan
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053917/
https://ncbi.nlm.nih.gov/pubmed/29559545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-1108
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