A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis and Metastasis in Aneuploid Cancers

Cyclin dependent kinase 2 (CDK2) antagonism inhibits clustering of excessive centrosomes at mitosis, causing multipolar cell division and apoptotic death. This is called anaphase catastrophe. To establish induced anaphase catastrophe as a clinically-tractable anti-neoplastic mechanism, induced anaph...

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I publikationen:Mol Cancer Ther
Huvudupphovsmän: Kawakami, Masanori, Mustachio, Lisa Maria, Chen, Yulong, Chen, Zibo, Liu, Xiuxia, Wei, Cheng-Hsin, Roszik, Jason, Kittai, Adam S., Danilov, Alexey V., Zhang, Xiaoshan, Fang, Bingliang, Wang, Jing, Heymach, John V., Tyutyunyk-Massey, Liliya, Freemantle, Sarah J., Kurie, Jonathan M., Liu, Xi, Dmitrovsky, Ethan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011823/
https://ncbi.nlm.nih.gov/pubmed/33277443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0987
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