CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110

Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacological targeting of aneuploidy is an attractive therapeutic strategy as this would preferentially eliminate malignant over normal cells. We previously discovered that CDK2 inhibition causes lung cancer c...

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Publicado no:Cancer Res
Main Authors: Hu, Shanhu, Danilov, Alexey V., Godek, Kristina, Orr, Bernardo, Tafe, Laura J., Rodriguez-Canales, Jaime, Behrens, Carmen, Mino, Barbara, Moran, Cesar A., Memoli, Vincent A., Mustachio, Lisa Maria, Galimberti, Fabrizio, Ravi, Saranya, DeCastro, Andrew, Lu, Yun, Sekula, David, Andrew, Angeline S, Wistuba, Ignacio I., Freemantle, Sarah, Compton, Duane A., Dmitrovsky, Ethan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433598/
https://ncbi.nlm.nih.gov/pubmed/25808870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1494
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