A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation

STAT transcription factors transduce signals from the cell surface to the nucleus, where they regulate the expression of genes that control proliferation, survival, self-renewal, and other critical cellular functions. Under normal physiological conditions, the activation of STATs is tightly regulate...

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Bibliografske podrobnosti
Main Authors: Nelson, Erik A., Sharma, Sreenath V., Settleman, Jeffrey, Frank, David A.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2011
Teme:
Research Perspectives
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248200/
https://ncbi.nlm.nih.gov/pubmed/21680956
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