Electroporation Delivery of DNA Vaccines: Prospects for Success

Por Sardesai, Niranjan Y., Weiner, David B.
Publicado em 2011

Induction of robust cellular immunity against HPV6 and HPV11 in mice by DNA vaccine encoding for E6/E7 antigen

Por Shin, Thomas, Pankhong, Panyupa, Yan, Jian, Khan, Amir S., Sardesai, Niranjan Y., Weiner, David B.
Publicado em 2012

Immunogenicity of a novel engineered HIV-1 clade C synthetic consensus-based envelope DNA vaccine

Por Yan, Jian, Corbitt, Natasha, Pankhong, Panyupa, Shin, Thomas, Khan, Amir, Sardesai, Niranjan Y., Weiner, David B.
Publicado em 2011

Unique Th1/Th2 Phenotypes Induced during Priming and Memory Phases by Use of Interleukin-12 (IL-12) or IL-28B Vaccine Adjuvants in Rhesus Macaques

Por Morrow, Matthew P., Yan, Jian, Pankhong, Panyupa, Ferraro, Bernadette, Lewis, Mark G., Khan, Amir S., Sardesai, Niranjan Y., Weiner, David B.
Publicado em 2010

Optimized In Vivo Transfer of Small Interfering RNA Targeting Dermal Tissue Using In Vivo Surface Electroporation

Por Broderick, Kate E, Chan, Amy, Lin, Feng, Shen, Xuefei, Kichaev, Gleb, Khan, Amir S, Aubin, Justin, Zimmermann, Tracy S, Sardesai, Niranjan Y.
Publicado em 2012

Electroporation mediated DNA vaccination directly to a mucosal surface results in improved immune responses

Por Kichaev, Gleb, Mendoza, Janess M, Amante, Dinah, Smith, Trevor RF, McCoy, Jay R, Sardesai, Niranjan Y, Broderick, Kate E
Publicado em 2013

Tolerability of intramuscular and intradermal delivery by CELLECTRA(®) adaptive constant current electroporation device in healthy volunteers

Por Diehl, Malissa C, Lee, Jessica C, Daniels, Stephen E, Tebas, Pablo, Khan, Amir S, Giffear, Mary, Sardesai, Niranjan Y, Bagarazzi, Mark L
Publicado em 2013

Direct Transfection of Dendritic Cells in the Epidermis After Plasmid Delivery Enhanced by Surface Electroporation

Por Amante, Dinah H., Smith, Trevor R.F., Kiosses, Bill B., Sardesai, Niranjan Y., Humeau, Laurent M.P.F., Broderick, Kate E.
Publicado no Hum Gene Ther Methods (2014)

VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus

Por Fagone, Paolo, Muthumani, Karuppiah, Mangano, Katia, Magro, Gaetano, Meroni, Pier Luigi, Kim, Joseph J, Sardesai, Niranjan Y, Weiner, David B, Nicoletti, Ferdinando
Publicado em 2014

Enhanced Delivery and Potency of Self-Amplifying mRNA Vaccines by Electroporation in Situ

Por Cu, Yen, Broderick, Kate E., Banerjee, Kaustuv, Hickman, Julie, Otten, Gillis, Barnett, Susan, Kichaev, Gleb, Sardesai, Niranjan Y., Ulmer, Jeffrey B., Geall, Andrew
Publicado no Vaccines (Basel) (2013)

A multi-head intradermal electroporation device allows for tailored and increased dose DNA vaccine delivery to the skin

Por McCoy, Jay R, Mendoza, Janess M, Spik, Kristin W, Badger, Catherine, Gomez, Alan F, Schmaljohn, Connie S, Sardesai, Niranjan Y, Broderick, Kate E
Publicado no Hum Vaccin Immunother (2015)

Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy

Por Flingai, Seleeke, Plummer, Emily M., Patel, Ami, Shresta, Sujan, Mendoza, Janess M., Broderick, Kate E., Sardesai, Niranjan Y., Muthumani, Kar, Weiner, David B.
Publicado no Sci Rep (2015)

A multi-head intradermal electroporation device allows for tailored and increased dose DNA vaccine delivery to the skin

Por McCoy, Jay R, Mendoza, Janess M, Spik, Kristin W, Badger, Catherine, Gomez, Alan F, Schmaljohn, Connie S, Sardesai, Niranjan Y, Broderick, Kate E
Publicado no Hum Vaccin Immunother (2014)

A Synthetic DNA, multi-neoantigen vaccine drives predominately MHC class I CD8(+) T-cell responses, impacting tumor challenge

Por Duperret, Elizabeth K., Perales-Puchalt, Alfredo, Stoltz, Regina, Hiranjith, G. H., Mandloi, Nitin, Barlow, James, Chaudhuri, Amitabha, Sardesai, Niranjan Y., Weiner, David B.
Publicado no Cancer Immunol Res (2019)

Recombinant rubella vectors elicit SIV Gag-specific T cell responses with cytotoxic potential in rhesus macaques

Por Rosati, Margherita, Alicea, Candido, Kulkarni, Viraj, Virnik, Konstantin, Hockenbury, Max, Sardesai, Niranjan Y., Pavlakis, George N., Valentin, Antonio, Berkower, Ira, Felber, Barbara K.
Publicado no Vaccine (2015)

Hepatitis C Virus NS3/NS4A DNA Vaccine Induces Multiepitope T Cell Responses in Rhesus Macaques Mimicking Human Immune Responses

Por Lang Kuhs, Krystle A, Ginsberg, Arielle A, Yan, Jian, Wiseman, Roger W, Khan, Amir S, Sardesai, Niranjan Y, O'Connor, David H, Weiner, David B
Publicado em 2012

Vaccination with synthetic constructs expressing cytomegalovirus immunogens is highly T cell immunogenic in mice

Por Shedlock, Devon J., Talbott, Kendra T., Wu, Stephan J., Wilson, Christine M., Muthumani, Karuppiah, Boyer, Jean D., Sardesai, Niranjan Y., Awasthi, Sita, Weiner, David B.
Publicado em 2012

Therapeutic DNA Vaccination Using In Vivo Electroporation Followed by Standard of Care Therapy in Patients With Genotype 1 Chronic Hepatitis C

Por Weiland, Ola, Ahlén, Gustaf, Diepolder, Helmut, Jung, Maria-Christina, Levander, Sepideh, Fons, Michael, Mathiesen, Iacob, Sardesai, Niranjan Y, Vahlne, Anders, Frelin, Lars, Sällberg, Matti
Publicado em 2013

Highly optimized DNA vaccine targeting human telomerase reverse transcriptase stimulates potent antitumor immunity

Por Yan, Jian, Pankhong, Panyupa, Shin, Thomas H., Obeng-Adjei, Nyamekye, Morrow, Matthew P., Walters, Jewell N., Khan, Amir S., Sardesai, Niranjan Y., Weiner, David B.
Publicado em 2013

Elucidating the Kinetics of Expression and Immune Cell Infiltration Resulting from Plasmid Gene Delivery Enhanced by Surface Dermal Electroporation

Por Mendoza, Janess M., Amante, Dinah H., Kichaev, Gleb, Knott, Christine L., Kiosses, William B., Smith, Trevor R. F., Sardesai, Niranjan Y., Broderick, Kate E.
Publicado no Vaccines (Basel) (2013)