Optimized In Vivo Transfer of Small Interfering RNA Targeting Dermal Tissue Using In Vivo Surface Electroporation

Electroporation (EP) of mammalian tissue is a technique that has been used successfully in the clinic for the delivery of genetic-based vaccines in the form of DNA plasmids. There is great interest in platforms which efficiently deliver RNA molecules such as messenger RNA and small interfering RNA (...

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Main Authors: Broderick, Kate E, Chan, Amy, Lin, Feng, Shen, Xuefei, Kichaev, Gleb, Khan, Amir S, Aubin, Justin, Zimmermann, Tracy S, Sardesai, Niranjan Y.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381603/
https://ncbi.nlm.nih.gov/pubmed/23344722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.1
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