CELL SIGNALLING: Binding the receptor at both ends

Por SPRANG, STEPHEN R.
Publicado em 2011

An Acid Test for G Proteins

Por Sprang, Stephen R.
Publicado em 2013

Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis

Por Sprang, Stephen R.
Publicado no Biopolymers (2016)

Transition State Structures and the Roles of Catalytic Residues in GAP-Facilitated GTPase of Ras As Elucidated by (18)O Kinetic Isotope Effects

Por Du, Xinlin, Sprang, Stephen R.
Publicado em 2009

CELL SIGNALING: Structural Origins of Receptor Bias

Por Sprang, Stephen R., Elk, Jackson Chief
Publicado em 2012

A Method to Determine (18)O Kinetic Isotope Effects in the Hydrolysis of Nucleotide Triphosphates

Por Du, Xinlin, Ferguson, Kurt, Sprang, Stephen R.
Publicado em 2007

Cosolvent-induced transformation of a death domain tertiary structure

Por Xiao, Tsan, Gardner, Kevin H., Sprang, Stephen R.
Publicado em 2002

Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF

Por Chen, Zhe, Guo, Liang, Sprang, Stephen R, Sternweis, Paul C
Publicado em 2011

Three-Dimensional Structure of a Complex between the Death Domains of Pelle and Tube

Por Xiao, Tsan, Towb, Par, Wasserman, Steven A., Sprang, Stephen R.
Publicado no Cell (1999)

Ric-8A Catalyzes Guanine Nucleotide Exchange on Gα(i1) Bound to the GPR/GoLoco Exchange Inhibitor AGS3

Por Thomas, Celestine J., Tall, Gregory G., Adhikari, Anirban, Sprang, Stephen R.
Publicado em 2008

Catalytic mechanism of mammalian adenylyl cyclase: a computational investigation

Por Hahn, David K., Tusell, Jose R, Sprang, Stephen R., Chu, Xi
Publicado no Biochemistry (2015)

STRUCTURAL BASIS FOR INHIBITION OF MAMMALIAN ADENYLYL CYCLASE BY CALCIUM

Por Mou, Tung—Chung, Masada, Nanako, Cooper, Dermot M. F., Sprang, Stephen R.
Publicado em 2009

Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits

Por Chan, PuiYee, Thomas, Celestine J., Sprang, Stephen R., Tall, Gregory G.
Publicado em 2013

The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1

Por Van Eps, Ned, Thomas, Celestine J., Hubbell, Wayne L., Sprang, Stephen R.
Publicado no Proc Natl Acad Sci U S A (2015)

Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα

Por Kant, Ravi, Zeng, Baisen, Thomas, Celestine J, Bothner, Brian, Sprang, Stephen R
Publicado no eLife (2016)

Kinetic isotope effects in Ras-catalyzed GTP hydrolysis: Evidence for a loose transition state

Por Du, Xinlin, Black, Gavin E., Lecchi, Paolo, Abramson, Fred P., Sprang, Stephen R.
Publicado em 2004

Inhibitors of Membranous Adenylyl Cyclases

Por Seifert, Roland, Lushington, Gerald H., Mou, Tung-Chung, Gille, Andreas, Sprang, Stephen R.
Publicado em 2011

Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c

Por Sinha, Sangita C, Wetterer, Martina, Sprang, Stephen R, Schultz, Joachim E, Linder, Jürgen U
Publicado em 2005

Recognition of the activated states of Gα13 by the rgRGS domain of PDZRhoGEF

Por Chen, Zhe, Singer, William D., Danesh, Shahab M., Sternweis, Paul C., Sprang, Stephen R.
Publicado em 2008

Activation of p115-RhoGEF Requires Direct Association of Gα(13) and the Dbl Homology Domain

Por Chen, Zhe, Guo, Liang, Hadas, Jana, Gutowski, Stephen, Sprang, Stephen R., Sternweis, Paul C.
Publicado em 2012