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Catalytic mechanism of mammalian adenylyl cyclase: a computational investigation
Adenylyl cyclase (AC) catalyzes the synthesis of cyclic AMP, an important intracellular regulatory molecule, from ATP. We propose a catalytic mechanism for Class III mammalian AC based on density functional theory calculations. We employ a model of the AC active site derived from a crystal structure...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5156327/ https://ncbi.nlm.nih.gov/pubmed/26393535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00655 |
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