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Catalytic mechanism of mammalian adenylyl cyclase: a computational investigation

Adenylyl cyclase (AC) catalyzes the synthesis of cyclic AMP, an important intracellular regulatory molecule, from ATP. We propose a catalytic mechanism for Class III mammalian AC based on density functional theory calculations. We employ a model of the AC active site derived from a crystal structure...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Hahn, David K., Tusell, Jose R, Sprang, Stephen R., Chu, Xi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156327/
https://ncbi.nlm.nih.gov/pubmed/26393535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00655
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