Differential Interactions of the Catalytic Subunits of Adenylyl Cyclase with Forskolin Analogs

The diterpene forskolin (FS) binds to, and activates, mammalian membranous adenylyl cyclase (AC) isoforms I–VIII. Diterpenes without C(1)-OH group do not activate ACs. The C(1)-OH group forms a hydrogen bond with the backbone oxygen of Val506 of the C1 catalytic subunit of AC (isoform V numbering)....

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Autores principales: Pinto, Cibele, Hübner, Melanie, Gille, Andreas, Richter, Mark, Mou, Tung-Chung, Sprang, Stephen R., Seifert, Roland
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692545/
https://ncbi.nlm.nih.gov/pubmed/19447224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.03.023
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