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Differential Interactions of the Catalytic Subunits of Adenylyl Cyclase with Forskolin Analogs
The diterpene forskolin (FS) binds to, and activates, mammalian membranous adenylyl cyclase (AC) isoforms I–VIII. Diterpenes without C(1)-OH group do not activate ACs. The C(1)-OH group forms a hydrogen bond with the backbone oxygen of Val506 of the C1 catalytic subunit of AC (isoform V numbering)....
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692545/ https://ncbi.nlm.nih.gov/pubmed/19447224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.03.023 |
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