Structure-Activity Relationships for the Interactions of 2’- and 3’-(O)-(N-Methyl)anthraniloyl-Substituted Purine and Pyrimidine Nucleotides with Mammalian Adenylyl Cyclases

Membranous adenylyl cyclases (ACs) play a key role in signal transduction and are promising drug targets. In previous studies we showed that 2’,3’-(O)-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent AC inhibitors. The aim of this study was to provide systematic structure-activity re...

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Main Authors: Pinto, Cibele, Lushington, Gerald H., Richter, Mark, Gille, Andreas, Geduhn, Jens, König, Burkhard, Mou, Tung-Chung, Sprang, Stephen R., Seifert, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138873/
https://ncbi.nlm.nih.gov/pubmed/21620805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.05.010
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