Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2′(3′)-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides

Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins: lethal factor, protective antigen, and edema factor (EF), a highly active calmodulin-dependent adenylyl cyclase (AC). However, conventional antibiotic treatment is ineffective against eith...

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Main Authors: Taha, Hesham M., Schmidt, Jennifer, Göttle, Martin, Suryanarayana, Srividya, Shen, Yuequan, Tang, Wei-Jen, Gille, Andreas, Geduhn, Jens, König, Burkhard, Dove, Stefan, Seifert, Roland
Format: Artigo
Language:Inglês
Published: American Society for Pharmacology and Experimental Therapeutics 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684916/
https://ncbi.nlm.nih.gov/pubmed/19056899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.052340
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