Structural Basis for the High-Affinity Inhibition of Mammalian Membranous Adenylyl Cyclase by 2′,3′-O-(N-Methylanthraniloyl)-Inosine 5′-Triphosphate

2′,3′-O-(N-Methylanthraniloyl)-ITP (MANT-ITP) is the most potent inhibitor of mammalian membranous adenylyl cyclase (mAC) 5 (AC5, K(i), 1 nM) yet discovered and surpasses the potency of MANT-GTP by 55-fold (J Pharmacol Exp Ther 329:1156–1165, 2009). AC5 inhibitors may be valuable drugs for treatment...

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Main Authors: Hübner, Melanie, Dixit, Anshuman, Mou, Tung-Chung, Lushington, Gerald H., Pinto, Cibele, Gille, Andreas, Geduhn, Jens, König, Burkhard, Sprang, Stephen R., Seifert, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127541/
https://ncbi.nlm.nih.gov/pubmed/21498658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.071894
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