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Adenylyl cyclase Rv1625c of Mycobacterium tuberculosis: a progenitor of mammalian adenylyl cyclases

The gene Rv1625c from Mycobacterium tuberculosis encodes a membrane-anchored adenylyl cyclase corresponding to exactly one-half of a mammalian adenylyl cyclase. An engineered, soluble form of Rv1625c was expressed in Escherichia coli. It formed a homodimeric cyclase with two catalytic centers. Amino...

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Detalhes bibliográficos
Main Authors: Guo, Ying Lan, Seebacher, Thomas, Kurz, Ursula, Linder, Jürgen U., Schultz, Joachim E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC125536/
https://ncbi.nlm.nih.gov/pubmed/11447108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.14.3667
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