Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c

Rv1900c, a Mycobacterium tuberculosis adenylyl cyclase, is composed of an N-terminal α/β-hydrolase domain and a C-terminal cyclase homology domain. It has an unusual 7% guanylyl cyclase side-activity. A canonical substrate-defining lysine and a catalytic asparagine indispensable for mammalian adenyl...

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Bibliographic Details
Main Authors: Sinha, Sangita C, Wetterer, Martina, Sprang, Stephen R, Schultz, Joachim E, Linder, Jürgen U
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC549627/
https://ncbi.nlm.nih.gov/pubmed/15678099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600573
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