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Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c
Rv1900c, a Mycobacterium tuberculosis adenylyl cyclase, is composed of an N-terminal α/β-hydrolase domain and a C-terminal cyclase homology domain. It has an unusual 7% guanylyl cyclase side-activity. A canonical substrate-defining lysine and a catalytic asparagine indispensable for mammalian adenyl...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC549627/ https://ncbi.nlm.nih.gov/pubmed/15678099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600573 |
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