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Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα
Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is a chaperone for several classes of heterotrimeric G protein α subunits in vertebrates. Using Hydrogen-Deuterium Exchange-Mass Spectrometry (HDX-MS) we show that Ric-8A disrupts the secondary structure of the Gα Ras-like do...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5182059/ https://ncbi.nlm.nih.gov/pubmed/28008853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19238 |
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