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Cosolvent-induced transformation of a death domain tertiary structure
The death domain (DD) of the protein kinase Pelle adopts a six-helix bundle fold in the crystal structure of the complex with its dimerization partner, Tube-DD. However, in crystals obtained from a solution of 45% 2-methyl-2,4-pentanediol (MPD), the C-terminal half of Pelle-DD folds into a single he...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC123225/ https://ncbi.nlm.nih.gov/pubmed/12177432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.172188399 |
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