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Cosolvent-induced transformation of a death domain tertiary structure

The death domain (DD) of the protein kinase Pelle adopts a six-helix bundle fold in the crystal structure of the complex with its dimerization partner, Tube-DD. However, in crystals obtained from a solution of 45% 2-methyl-2,4-pentanediol (MPD), the C-terminal half of Pelle-DD folds into a single he...

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Detalhes bibliográficos
Main Authors: Xiao, Tsan, Gardner, Kevin H., Sprang, Stephen R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC123225/
https://ncbi.nlm.nih.gov/pubmed/12177432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.172188399
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