Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli

por Hodgson, David, Rowan, Andrew D., Falciani, Francesco, Proctor, Carole J.
Publicado en PLoS Comput Biol (2019)

A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL

por Hui, Wang, Cawston, Tim E, Richards, Carl D, Rowan, Andrew D
Publicado 2005

Adenoviral Gene Transfer of Interleukin-1 in Combination with Oncostatin M Induces Significant Joint Damage in a Murine Model

por Rowan, Andrew D., Hui, Wang, Cawston, Tim E., Richards, Carl D.
Publicado 2003

Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis

por Milner, Jennifer M, Rowan, Andrew D, Cawston, Tim E, Young, David A
Publicado 2006

Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics

por Wilkinson, David J, Arques, Maria del Carmen, Huesa, Carmen, Rowan, Andrew D
Publicado en Br J Pharmacol (2018)

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage

por Hui, Wang, Young, David A, Rowan, Andrew D, Xu, Xin, Cawston, Tim E, Proctor, Carole J
Publicado en Ann Rheum Dis (2016)

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts

por Williams, Rachel C., Skelton, Andrew J., Todryk, Stephen M., Rowan, Andrew D., Preshaw, Philip M., Taylor, John J.
Publicado en PLoS One (2016)

Macrophage Migration and Invasion Is Regulated by MMP10 Expression

por Murray, Megan Y., Birkland, Timothy P., Howe, Jonathan D., Rowan, Andrew D., Fidock, Mark, Parks, William C., Gavrilovic, Jelena
Publicado 2013

Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes

por Baker, Jonathan, Falconer, Adrian M. D., Wilkinson, David J., Europe-Finner, G. Nicholas, Litherland, Gary J., Rowan, Andrew D.
Publicado en PLoS One (2018)

Antigen-specific B lymphocytes acquire proteoglycan aggrecan from cartilage extracellular matrix resulting in antigen presentation and CD4(+) T-cell activation

por Ciechomska, Marzena, Wilson, Caroline L, Floudas, Achilleas, Hui, Wang, Rowan, Andrew D, van Eden, Willem, Robinson, John H, Knight, Andrew M
Publicado 2014

Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation

por Chan, Chun Ming, Macdonald, Christopher D., Litherland, Gary J., Wilkinson, David J., Skelton, Andrew, Europe-Finner, G. Nicholas, Rowan, Andrew D.
Publicado en J Biol Chem (2017)

Protein Kinase C Isoforms ζ and ι Mediate Collagenase Expression and Cartilage Destruction via STAT3- and ERK-dependent c-fos Induction

por Litherland, Gary J., Elias, Martina S., Hui, Wang, Macdonald, Christopher D., Catterall, Jonathon B., Barter, Matt J., Farren, Matthew J., Jefferson, Matthew, Rowan, Andrew D.
Publicado 2010

Differential Toll-like receptor-dependent collagenase expression in chondrocytes

por Zhang, Qian, Hui, Wang, Davidson, Rose, Darrah, Clare, Donell, Simon T, Clark, Ian M, Cawston, Tim E, Robinson, John H, Rowan, Andrew D, Young, David A
Publicado 2007

Collagenolytic matrix metalloproteinases antagonize proteinase-activated receptor-2 activation, providing insights into extracellular matrix turnover

por Falconer, Adrian M. D., Chan, Chun Ming, Gray, Joseph, Nagashima, Izuru, Holland, Robert A., Shimizu, Hiroki, Pickford, Andrew R., Rowan, Andrew D., Wilkinson, David J.
Publicado en J Biol Chem (2019)

Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes

por Macdonald, Christopher D., Falconer, Adrian M. D., Chan, Chun Ming, Wilkinson, David J., Skelton, Andrew, Reynard, Louise, Litherland, Gary J., Europe-Finner, G. Nicholas, Rowan, Andrew D.
Publicado en PLoS One (2018)

Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis

por Milner, Jennifer M, Kevorkian, Lara, Young, David A, Jones, Debra, Wait, Robin, Donell, Simon T, Barksby, Emma, Patterson, Angela M, Middleton, Jim, Cravatt, Benjamin F, Clark, Ian M, Rowan, Andrew D, Cawston, Timothy E
Publicado 2006

Matriptase Induction of Metalloproteinase‐Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms

por Wilkinson, David J., Habgood, Angela, Lamb, Heather K., Thompson, Paul, Hawkins, Alastair R., Désilets, Antoine, Leduc, Richard, Steinmetzer, Torsten, Hammami, Maya, Lee, Melody S., Craik, Charles S., Watson, Sharon, Lin, Hua, Milner, Jennifer M., Rowan, Andrew D.
Publicado en Arthritis Rheumatol (2017)

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

por Huesa, Carmen, Ortiz, Ana C, Dunning, Lynette, McGavin, Laura, Bennett, Louise, McIntosh, Kathryn, Crilly, Anne, Kurowska-Stolarska, Mariola, Plevin, Robin, van ‘t Hof, Rob J, Rowan, Andrew D, McInnes, Iain B, Goodyear, Carl S, Lockhart, John C, Ferrell, William R
Publicado en Ann Rheum Dis (2016)

The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover

por Wilkinson, David J., Desilets, Antoine, Lin, Hua, Charlton, Sarah, del Carmen Arques, Maria, Falconer, Adrian, Bullock, Craig, Hsu, Yu-Chen, Birchall, Kristian, Hawkins, Alastair, Thompson, Paul, Ferrell, William R., Lockhart, John, Plevin, Robin, Zhang, Yadan, Blain, Emma, Lin, Shu-Wha, Leduc, Richard, Milner, Jennifer M., Rowan, Andrew D.
Publicado en Sci Rep (2017)