Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts

INTRODUCTION: Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in the gingiva, human gingival fibroblasts express...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Williams, Rachel C., Skelton, Andrew J., Todryk, Stephen M., Rowan, Andrew D., Preshaw, Philip M., Taylor, John J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2016
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734666/
https://ncbi.nlm.nih.gov/pubmed/26829555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148024
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