Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation

Irreversible breakdown of cartilage extracellular matrix (ECM) by the collagenase matrix metalloproteinase 13 (MMP13) represents a key event in osteoarthritis (OA) progression. Although inflammation is most commonly associated with inflammatory joint diseases, it also occurs in OA and is thus releva...

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Vydáno v:J Biol Chem
Hlavní autoři: Chan, Chun Ming, Macdonald, Christopher D., Litherland, Gary J., Wilkinson, David J., Skelton, Andrew, Europe-Finner, G. Nicholas, Rowan, Andrew D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290940/
https://ncbi.nlm.nih.gov/pubmed/27956552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.756601
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