Protein Kinase C Isoforms ζ and ι Mediate Collagenase Expression and Cartilage Destruction via STAT3- and ERK-dependent c-fos Induction

The protein kinase C (PKC) signaling pathway is a major regulator of cellular functions and is implicated in pathologies involving extracellular matrix remodeling. Inflammatory joint disease is characterized by excessive extracellular matrix catabolism, and here we assess the role of PKC in the indu...

Full description

Saved in:
Bibliographic Details
Main Authors: Litherland, Gary J., Elias, Martina S., Hui, Wang, Macdonald, Christopher D., Catterall, Jonathon B., Barter, Matt J., Farren, Matthew J., Jefferson, Matthew, Rowan, Andrew D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903406/
https://ncbi.nlm.nih.gov/pubmed/20463008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.120121
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items