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Protein Kinase C Isoforms ζ and ι Mediate Collagenase Expression and Cartilage Destruction via STAT3- and ERK-dependent c-fos Induction
The protein kinase C (PKC) signaling pathway is a major regulator of cellular functions and is implicated in pathologies involving extracellular matrix remodeling. Inflammatory joint disease is characterized by excessive extracellular matrix catabolism, and here we assess the role of PKC in the indu...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903406/ https://ncbi.nlm.nih.gov/pubmed/20463008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.120121 |
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