Protein Kinase C Isoforms ζ and ι Mediate Collagenase Expression and Cartilage Destruction via STAT3- and ERK-dependent c-fos Induction

The protein kinase C (PKC) signaling pathway is a major regulator of cellular functions and is implicated in pathologies involving extracellular matrix remodeling. Inflammatory joint disease is characterized by excessive extracellular matrix catabolism, and here we assess the role of PKC in the indu...

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Bibliografiske detaljer
Main Authors: Litherland, Gary J., Elias, Martina S., Hui, Wang, Macdonald, Christopher D., Catterall, Jonathon B., Barter, Matt J., Farren, Matthew J., Jefferson, Matthew, Rowan, Andrew D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903406/
https://ncbi.nlm.nih.gov/pubmed/20463008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.120121
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