Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes

Many catabolic stimuli, including interleukin-1 (IL-1) in combination with oncostatin M (OSM), promote cartilage breakdown via the induction of collagen-degrading collagenases such as matrix metalloproteinase 1 (MMP1) and MMP13 in human articular chondrocytes. Indeed, joint diseases with an inflamma...

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Udgivet i:PLoS One
Main Authors: Baker, Jonathan, Falconer, Adrian M. D., Wilkinson, David J., Europe-Finner, G. Nicholas, Litherland, Gary J., Rowan, Andrew D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898748/
https://ncbi.nlm.nih.gov/pubmed/29652915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195864
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