The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover

Increasing evidence implicates serine proteinases in the proteolytic cascades leading to the pathological destruction of extracellular matrices such as cartilage in osteoarthritis (OA). We have previously demonstrated that the type II transmembrane serine proteinase (TTSP) matriptase acts as a novel...

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Publicado no:Sci Rep
Main Authors: Wilkinson, David J., Desilets, Antoine, Lin, Hua, Charlton, Sarah, del Carmen Arques, Maria, Falconer, Adrian, Bullock, Craig, Hsu, Yu-Chen, Birchall, Kristian, Hawkins, Alastair, Thompson, Paul, Ferrell, William R., Lockhart, John, Plevin, Robin, Zhang, Yadan, Blain, Emma, Lin, Shu-Wha, Leduc, Richard, Milner, Jennifer M., Rowan, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711915/
https://ncbi.nlm.nih.gov/pubmed/29196708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17028-3
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