Mapping sequence differences between thimet oligopeptidase and neurolysin implicates key residues in substrate recognition

Por Ray, Kallol, Hines, Christina S., Rodgers, David W.
Publicado em 2002

6-Carboxyfluorescein And Structurally-Similar Molecules Inhibit DNA Binding And Repair By O(6)-Alkylguanine DNA Alkyltransferase

Por Melikishvili, Manana, Rodgers, David W., Fried, Michael G.
Publicado em 2011

Phenomenological Partial Specific Volumes for G-Quadruplex DNAs

Por Hellman, Lance M., Rodgers, David W., Fried, Michael G.
Publicado em 2009

A Monomeric Variant of Insulin Degrading Enzyme (IDE) Loses Its Regulatory Properties

Por Song, Eun Suk, Rodgers, David W., Hersh, Louis B.
Publicado em 2010

Mixed Dimers of Insulin-degrading Enzyme Reveal a Cis Activation Mechanism

Por Song, Eun Suk, Rodgers, David W., Hersh, Louis B.
Publicado em 2011

Insulin-degrading enzyme is not secreted from cultured cells

Por Song, Eun Suk, Rodgers, David W., Hersh, Louis B.
Publicado no Sci Rep (2018)

Active Site Mutations Change the Cleavage Specificity of Neprilysin

Por Sexton, Travis, Hitchcook, Lisa J., Rodgers, David W., Bradley, Luke H., Hersh, Louis B.
Publicado em 2012

Mechanism-informed refinement reveals altered substrate-binding mode for catalytically competent nitroreductase

Por Pitsawong, Warintra, Haynes, Chad A., Koder, Ronald L., Rodgers, David W., Miller, Anne-Frances
Publicado no Structure (2017)

Structure of neurolysin reveals a deep channel that limits substrate access

Por Brown, C. Kent, Madauss, Kevin, Lian, Wei, Beck, Moriah R., Tolbert, W. David, Rodgers, David W.
Publicado em 2001

Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders

Por Cai, Yiying, Cronin, Ciarán N, Engel, Andrew G, Ohno, Kinji, Hersh, Louis B, Rodgers, David W
Publicado em 2004

TOPOLOGIES OF COMPLEXES CONTAINING O(6)-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND DNA

Por Adams, Claire A., Melikishvili, Manana, Rodgers, David W., Rasimas, Joseph J., Pegg, Anthony E., Fried, Michael G.
Publicado em 2009

Anion Activation Site of Insulin-degrading Enzyme

Por Noinaj, Nicholas, Song, Eun Suk, Bhasin, Sonia, Alper, Benjamin J., Schmidt, Walter K., Hersh, Louis B., Rodgers, David W.
Publicado em 2012

Cysteine 904 Is Required for Maximal Insulin Degrading Enzyme Activity and Polyanion Activation

Por Song, Eun Suk, Melikishvili, Manana, Fried, Michael G., Juliano, Maria A., Juliano, Luiz, Rodgers, David W., Hersh, Louis B.
Publicado em 2012

Rational Design, Preparation, and Characterization of a Therapeutic Enzyme Mutant with Improved Stability and Function for Cocaine Detoxification

Por Fang, Lei, Chow, K. Martin, Hou, Shurong, Xue, Liu, Chen, Xiabin, Rodgers, David W., Zheng, Fang, Zhan, Chang-Guo
Publicado em 2014

Identification of the Allosteric Regulatory Site of Insulysin

Por Noinaj, Nicholas, Bhasin, Sonia K., Song, Eun Suk, Scoggin, Kirsten E., Juliano, Maria A., Juliano, Luiz, Hersh, Louis B., Rodgers, David W.
Publicado em 2011

REDUCTION OF AMYLOID-BETA LEVELS IN MOUSE EYE TISSUES BY INTRA-VITREALLY DELIVERED NEPRILYSIN

Por Parthasarathy, Rajni, Chow, K. Martin, Derafshi, Zahra, Fautsch, Michael P., Hetling, John R., Rodgers, David W., Hersh, Louis B., Pepperberg, David R.
Publicado no Exp Eye Res (2015)

Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells

Por Chin-Chan, Miguel, Segovia, José, Quintanar, Liliana, Arcos-López, Trinidad, Hersh, Louis B., Chow, K. Martin, Rodgers, David W., Quintanilla-Vega, Betzabet
Publicado no Toxicol Sci (2015)

An Extended Polyanion Activation Surface in Insulin Degrading Enzyme

Por Song, Eun Suk, Ozbil, Mehmet, Zhang, Tingting, Sheetz, Michael, Lee, David, Tran, Danny, Li, Sheng, Prabhakar, Rajeev, Hersh, Louis B., Rodgers, David W.
Publicado no PLoS One (2015)

Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes

Por Song, Eun Suk, Jang, HyeIn, Guo, Hou-Fu, Juliano, Maria A., Juliano, Luiz, Morris, Andrew J., Galperin, Emilia, Rodgers, David W., Hersh, Louis B.
Publicado no Proc Natl Acad Sci U S A (2017)

The structural basis for activation of the Rab Ypt1p by the TRAPP membrane tethering complexes

Por Cai, Yiying, Chin, Harvey F., Lazarova, Darina, Menon, Shekar, Fu, Chunmei, Cai, Huaqing, Sclafani, Anthony, Rodgers, David W., De La Cruz, Enrique M., Ferro-Novick, Susan, Reinisch, Karin M.
Publicado em 2008