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Mixed Dimers of Insulin-degrading Enzyme Reveal a Cis Activation Mechanism
Insulin-degrading enzyme (IDE) exists primarily as a dimer being unique among the zinc metalloproteases in that it exhibits allosteric kinetics with small synthetic peptide substrates. In addition the IDE reaction rate is increased by small peptides that bind to a distal site within the substrate bi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077586/ https://ncbi.nlm.nih.gov/pubmed/21343292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.191668 |
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