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Cysteine 904 Is Required for Maximal Insulin Degrading Enzyme Activity and Polyanion Activation
Cysteine residues in insulin degrading enzyme have been reported as non-critical for its activity. We found that converting the twelve cysteine residues in rat insulin degrading enzyme (IDE) to serines resulted in a cysteine-free form of the enzyme with reduced activity and decreased activation by p...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3471918/ https://ncbi.nlm.nih.gov/pubmed/23077523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046790 |
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