Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes

Insulin-degrading enzyme (IDE) hydrolyzes bioactive peptides, including insulin, amylin, and the amyloid β peptides. Polyanions activate IDE toward some substrates, yet an endogenous polyanion activator has not yet been identified. Here we report that inositol phosphates (InsPs) and phosphatdidylino...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Song, Eun Suk, Jang, HyeIn, Guo, Hou-Fu, Juliano, Maria A., Juliano, Luiz, Morris, Andrew J., Galperin, Emilia, Rodgers, David W., Hersh, Louis B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389272/
https://ncbi.nlm.nih.gov/pubmed/28325868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613447114
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