Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes

Insulin-degrading enzyme (IDE) hydrolyzes bioactive peptides, including insulin, amylin, and the amyloid β peptides. Polyanions activate IDE toward some substrates, yet an endogenous polyanion activator has not yet been identified. Here we report that inositol phosphates (InsPs) and phosphatdidylino...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Song, Eun Suk, Jang, HyeIn, Guo, Hou-Fu, Juliano, Maria A., Juliano, Luiz, Morris, Andrew J., Galperin, Emilia, Rodgers, David W., Hersh, Louis B.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389272/
https://ncbi.nlm.nih.gov/pubmed/28325868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613447114
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki