Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

3-phosphoinositide-dependent protein kinase-1 (PDK1) phosphorylates and activates many kinases belonging to the AGC subfamily. PDK1 possesses a C-terminal pleckstrin homology (PH) domain that interacts with PtdIns(3,4,5)P(3)/PtdIns(3,4)P(2) and with lower affinity to PtdIns(4,5)P(2). We describe the...

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Main Authors: Komander, David, Fairservice, Alison, Deak, Maria, Kular, Gursant S, Prescott, Alan R, Peter Downes, C, Safrany, Stephen T, Alessi, Dario R, van Aalten, Daan M F
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2004
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC524332/
https://ncbi.nlm.nih.gov/pubmed/15457207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600379
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