Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.

PDK1 (3-phosphoinositide-dependent protein kinase-1) is a member of the AGC (cAMP-dependent, cGMP-dependent, protein kinase C) family of protein kinases, and has a key role in insulin and growth-factor signalling through phosphorylation and subsequent activation of a number of other AGC kinase famil...

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Hlavní autoři: Komander, David, Kular, Gursant S, Bain, Jennifer, Elliott, Matthew, Alessi, Dario R, Van Aalten, Daan M F
Médium: Artigo
Jazyk:Inglês
Vydáno: 2003
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223700/
https://ncbi.nlm.nih.gov/pubmed/12892559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031119
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