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High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site
3-phosphoinositide dependent protein kinase-1 (PDK1) plays a key role in regulating signalling pathways by activating AGC kinases such as PKB/Akt and S6K. Here we describe the 2.0 Å crystal structure of the PDK1 kinase domain in complex with ATP. The structure defines the hydrophobic pocket termed t...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126174/ https://ncbi.nlm.nih.gov/pubmed/12169624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf437 |
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