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In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

PKB/Akt, S6K, SGK and RSK are mediators of responses triggered by insulin and growth factors and are activated following phosphorylation by 3-phosphoinositide-dependent protein kinase-1 (PDK1). To investigate the importance of a substrate-docking site in the kinase domain of PDK1 termed the ‘PIF-poc...

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Bibliografiske detaljer
Main Authors: Collins, Barry J., Deak, Maria, Arthur, J.Simon C., Armit, Laura J., Alessi, Dario R.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC175797/
https://ncbi.nlm.nih.gov/pubmed/12912918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg407
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