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High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

3-phosphoinositide dependent protein kinase-1 (PDK1) plays a key role in regulating signalling pathways by activating AGC kinases such as PKB/Akt and S6K. Here we describe the 2.0 Å crystal structure of the PDK1 kinase domain in complex with ATP. The structure defines the hydrophobic pocket termed t...

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Dettagli Bibliografici
Autori principali: Biondi, Ricardo M., Komander, David, Thomas, Christine C., Lizcano, Jose M., Deak, Maria, Alessi, Dario R., van Aalten, Daan M.F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC126174/
https://ncbi.nlm.nih.gov/pubmed/12169624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf437
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