An efficient and versatile synthesis of GlcNAcstatins—potent and selective O-GlcNAcase inhibitors built on the tetrahydroimidazo[1,2-a]pyridine scaffold

Por Borodkin, Vladimir S., van Aalten, Daan M.F.
Publicado em 2010

Native detection of protein O-GlcNAcylation by gel electrophoresis

Por Fu, Chuan, van Aalten, Daan M.F.
Publicado no Analyst (2020)

Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds

Por Dorfmueller, Helge C., van Aalten, Daan M.F.
Publicado em 2010

A sweet TET-à-tête-synergy of TET proteins and O-GlcNAc transferase in transcription

Por Mariappa, Daniel, Pathak, Shalini, van Aalten, Daan M F
Publicado em 2013

O-GlcNAcase: Promiscuous Hexosaminidase or Key Regulator of O-GlcNAc Signaling?

Por Alonso, Jana, Schimpl, Marianne, van Aalten, Daan M. F.
Publicado no J Biol Chem (2014)

Effects of hypo-O-GlcNAcylation on Drosophila development

Por Mariappa, Daniel, Ferenbach, Andrew T., van Aalten, Daan M. F.
Publicado no J Biol Chem (2018)

A mouse model for functional dissection of TAB1 O-GlcNAcylation

Por Authier, Florence, Muha, Villő, van Aalten, Daan M.F.
Publicado no Wellcome Open Res (2020)

O-GlcnAc transfer: size matters

Por Gay, Laurie M, Zheng, Xiaowei, van Aalten, Daan M F
Publicado em 2011

The structural basis of acyl coenzyme A-dependent regulation of the transcription factor FadR

Por van Aalten, Daan M.F., DiRusso, Concetta C., Knudsen, Jens
Publicado em 2001

Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins

Por Trapannone, Riccardo, Mariappa, Daniel, Ferenbach, Andrew T., vanAalten, Daan M.F.
Publicado no Biochem J (2016)

Evidence for substrate-assisted catalysis in N-acetylphosphoglucosamine mutase

Por Raimi, Olawale G., Hurtado-Guerrero, Ramon, vanAalten, Daan M.F.
Publicado no Biochem J (2018)

Chemical Dissection of the Link between Streptozotocin, O-GlcNAc, and Pancreatic Cell Death

Por Pathak, Shalini, Dorfmueller, Helge C., Borodkin, Vladimir S., van Aalten, Daan M.F.
Publicado em 2008

GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation

Por Dorfmueller, Helge C., Borodkin, Vladimir S., Schimpl, Marianne, van Aalten, Daan M. F.
Publicado em 2009

Human OGA binds substrates in a conserved peptide recognition groove

Por Schimpl, Marianne, Schüttelkopf, Alexander W., Borodkin, Vladimir S., van Aalten, Daan M. F.
Publicado em 2010

Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition

Por Schimpl, Marianne, Borodkin, Vladimir S., Gray, Lindsey J., van Aalten, Daan M.F.
Publicado em 2012

A Structural and Biochemical Model of Processive Chitin Synthesis

Por Dorfmueller, Helge C., Ferenbach, Andrew T., Borodkin, Vladimir S., van Aalten, Daan M. F.
Publicado em 2014

A missense mutation in a patient with developmental delay affects the activity and structure of the hexosamine biosynthetic pathway enzyme AGX1

Por Chen, Xiping, Raimi, Olawale G., Ferenbach, Andrew T., van Aalten, Daan M.F.
Publicado no FEBS Lett (2020)

The transfer of transthyretin and receptor-binding properties from the plasma retinol-binding protein to the epididymal retinoic acid-binding protein.

Por Sundaram, Manickavasagam, van Aalten, Daan M F, Findlay, John B C, Sivaprasadarao, Asipu
Publicado em 2002

Charge-Surrounded Pockets and Electrostatic Interactions with Small Ions Modulate the Activity of Retroviral Fusion Proteins

Por Lamb, Daniel, Schüttelkopf, Alexander W., van Aalten, Daan M. F., Brighty, David W.
Publicado em 2011

Comparative structural analysis of retroviral fusion proteins identifies regions that modulate membrane fusion: a potential retroviral achilles heal?

Por Lamb, Daniel, Schüttelkopf, Alexander W, van Aalten, Daan M F, Brighty, David W
Publicado em 2011