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Chemical Dissection of the Link between Streptozotocin, O-GlcNAc, and Pancreatic Cell Death
Streptozotocin is a natural product that selectively kills insulin-secreting β cells, and is widely used to generate mouse models of diabetes or treat pancreatic tumors. Several studies suggest that streptozotocin toxicity stems from its N-nitrosourea moiety releasing nitric oxide and possessing DNA...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2568864/ https://ncbi.nlm.nih.gov/pubmed/18721751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.06.010 |
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