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Chemical Dissection of the Link between Streptozotocin, O-GlcNAc, and Pancreatic Cell Death

Streptozotocin is a natural product that selectively kills insulin-secreting β cells, and is widely used to generate mouse models of diabetes or treat pancreatic tumors. Several studies suggest that streptozotocin toxicity stems from its N-nitrosourea moiety releasing nitric oxide and possessing DNA...

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Bibliografiske detaljer
Main Authors: Pathak, Shalini, Dorfmueller, Helge C., Borodkin, Vladimir S., van Aalten, Daan M.F.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568864/
https://ncbi.nlm.nih.gov/pubmed/18721751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.06.010
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