Structural insights into mechanism and specificity of O-GlcNAc transferase

Post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. O-GlcNAcylation is regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase, both encod...

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Detalhes bibliográficos
Main Authors: Clarke, Andrew J, Hurtado-Guerrero, Ramon, Pathak, Shalini, Schüttelkopf, Alexander W, Borodkin, Vladimir, Shepherd, Sharon M, Ibrahim, Adel F M, van Aalten, Daan M F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556091/
https://ncbi.nlm.nih.gov/pubmed/18818698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.186
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