The structural basis of acyl coenzyme A-dependent regulation of the transcription factor FadR

FadR is an acyl-CoA-responsive transcription factor, regulating fatty acid biosynthetic and degradation genes in Escherichia coli. The apo-protein binds DNA as a homodimer, an interaction that is disrupted by binding of acyl-CoA. The recently described structure of apo-FadR shows a DNA binding domai...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	van Aalten, Daan M.F., DiRusso, Concetta C., Knudsen, Jens
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125426/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11296236/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.8.2041
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