Human OGA binds substrates in a conserved peptide recognition groove

Modification of cellular proteins with O-GlcNAc (O-linked N-acetylglucosamine) competes with protein phosphorylation and regulates a plethora of cellular processes. O-GlcNAcylation is orchestrated by two opposing enzymes, O-GlcNAc transferase and OGA (O-GlcNAcase or β-N-acetylglucosaminidase), which...

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Detalles Bibliográficos
Main Authors: Schimpl, Marianne, Schüttelkopf, Alexander W., Borodkin, Vladimir S., van Aalten, Daan M. F.
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2010
Assuntos:
Accelerated Publication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973230/
https://ncbi.nlm.nih.gov/pubmed/20863279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20101338
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