Turning liabilities into opportunities: Off-target based drug repurposing in cancer

by Palve, Vinayak, Liao, Yi, Remsing Rix, Lily L., Rix, Uwe
Published in Semin Cancer Biol (2020)

Chemoproteomics reveals novel protein and lipid kinase targets of clinical CDK4/6 inhibitors in lung cancer

by Sumi, Natalia J., Kuenzi, Brent M., Knezevic, Claire E., Rix, Lily L. Remsing, Rix, Uwe
Published in ACS Chem Biol (2015)

Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia

by Kuenzi, Brent M., Remsing Rix, Lily L., Kinose, Fumi, Kroeger, Jodi L., Lancet, Jeffrey E., Padron, Eric, Rix, Uwe
Published in Sci Rep (2019)

Lowering Sample Requirements to Study Tyrosine Kinase Signaling Using Phosphoproteomics with the TMT Calibrator Approach

by Fang, Bin, Izumi, Victoria, Remsing Rix, Lily L., Welsh, Eric, Pike, Ian, Reuther, Gary W., Haura, Eric B., Rix, Uwe, Koomen, John M.
Published in Proteomics (2020)

Dabrafenib inhibits the growth of BRAF‐WT cancers through CDK16 and NEK9 inhibition

by Phadke, Manali, Remsing Rix, Lily L., Smalley, Inna, Bryant, Annamarie T., Luo, Yunting, Lawrence, Harshani R., Schaible, Braydon J., Chen, Yian A., Rix, Uwe, Smalley, Keiran S. M.
Published in Mol Oncol (2017)

GSK3 alpha and beta are new functionally relevant targets of tivantinib in lung cancer cells

by Remsing Rix, Lily L., Kuenzi, Brent M., Luo, Yunting, Remily-Wood, Elizabeth, Kinose, Fumi, Wright, Gabriela, Li, Jiannong, Koomen, John M., Haura, Eric B., Lawrence, Harshani R., Rix, Uwe
Published 2013

Dual targeting of WEE1 and PLK1 by AZD1775 elicits single agent cellular anticancer activity

by Wright, Gabriela, Golubeva, Volha, Remsing Rix, Lily L., Berndt, Norbert, Luo, Yunting, Ward, Grace A., Gray, Jhanelle E., Schonbrunn, Ernst, Lawrence, Harshani R., Monteiro, Alvaro N.A., Rix, Uwe
Published in ACS Chem Biol (2017)

Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells

by Ctortecka, Claudia, Palve, Vinayak, Kuenzi, Brent M., Fang, Bin, Sumi, Natalia J., Izumi, Victoria, Novakova, Silvia, Kinose, Fumi, Remsing Rix, Lily L., Haura, Eric B., Koomen, John Matthew, Rix, Uwe
Published in Mol Cell Proteomics (2018)

Characterization of epidermal growth factor receptor (EGFR) P848L, an unusual EGFR variant present in lung cancer patients, in a murine Ba/F3 model

by Sarcar, Bhaswati, Gimbrone, Nicholas T., Wright, Gabriela, Remsing Rix, Lily L., Gordian, Edna R., Rix, Uwe, Chiappori, Alberto A., Reuther, Gary W., Santiago‐Cardona, Pedro G., Muñoz‐Antonia, Teresita, Cress, William Douglas
Published in FEBS Open Bio (2019)

A Target-Disease Network Model of Second-Generation BCR-ABL Inhibitor Action in Ph+ ALL

by Rix, Uwe, Colinge, Jacques, Blatt, Katharina, Gridling, Manuela, Remsing Rix, Lily L., Parapatics, Katja, Cerny-Reiterer, Sabine, Burkard, Thomas R., Jäger, Ulrich, Melo, Junia V., Bennett, Keiryn L., Valent, Peter, Superti-Furga, Giulio
Published 2013

Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells

by Kim, Jae-Young, Welsh, Eric A., Oguz, Umut, Fang, Bin, Bai, Yun, Kinose, Fumi, Bronk, Crystina, Remsing Rix, Lily L., Beg, Amer A., Rix, Uwe, Eschrich, Steven A., Koomen, John M., Haura, Eric B.
Published 2013

Proteome-wide profiling of clinical PARP inhibitors reveals compound-specific secondary targets

by Knezevic, Claire E., Wright, Gabriela, Rix, Lily L. Remsing, Kim, Woosuk, Kuenzi, Brent M., Luo, Yunting, Watters, January M., Koomen, John M., Haura, Eric B., Monteiro, Alvaro N., Radu, Caius, Lawrence, Harshani R., Rix, Uwe
Published in Cell Chem Biol (2016)

PAXIP1 potentiates the combination of WEE1 inhibitor AZD1775 and platinum agents in lung cancer

by Jhuraney, Ankita, Woods, Nicholas T., Wright, Gabriela, Rix, Lily, Kinose, Fumi, Kroeger, Jodi L., Remily-Wood, Elizabeth, Cress, W. Douglas, Koomen, John M., Brantley, Stephen G., Gray, Jhanelle E., Haura, Eric B., Rix, Uwe, Monteiro, Alvaro N.
Published in Mol Cancer Ther (2016)

Divergent polypharmacology-driven cellular activity of structurally similar multi-kinase inhibitors through cumulative effects on individual targets

by Sumi, Natalia J., Ctortecka, Claudia, Hu, Qianqian, Bryant, Annamarie T., Fang, Bin, Rix, Lily L. Remsing, Ayaz, Muhammad, Kinose, Fumi, Welsh, Eric A., Eschrich, Steven A., Lawrence, Harshani R., Koomen, John M., Haura, Eric B., Rix, Uwe
Published in Cell Chem Biol (2019)