PAXIP1 potentiates the combination of WEE1 inhibitor AZD1775 and platinum agents in lung cancer

The DNA damage response (DDR) involves a complex network of signaling events mediated by modular protein domains such as the BRCT (BRCA1 C-terminal) domain. Thus, proteins that interact with BRCT domains and are a part of the DDR constitute potential targets for sensitization to DNA damaging chemoth...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Jhuraney, Ankita, Woods, Nicholas T., Wright, Gabriela, Rix, Lily, Kinose, Fumi, Kroeger, Jodi L., Remily-Wood, Elizabeth, Cress, W. Douglas, Koomen, John M., Brantley, Stephen G., Gray, Jhanelle E., Haura, Eric B., Rix, Uwe, Monteiro, Alvaro N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936941/
https://ncbi.nlm.nih.gov/pubmed/27196765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0182
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