Effect of food on the pharmacokinetics of the WEE1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors

PURPOSE: To support future dosing recommendations, the effect of food on the pharmacokinetics of adavosertib, a first-in-class, small-molecule reversible inhibitor of WEE1 kinase, was assessed in patients with advanced solid tumors. METHODS: In this Phase I, open-label, randomized, two-period, two-s...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Cancer Chemother Pharmacol
Huvudupphovsmän: Någård, Mats, Ah-See, Mei-Lin, So, Karen, Vermunt, Marit, Thistlethwaite, Fiona, Labots, Mariette, Roxburgh, Patricia, Ravaud, Alain, Campone, Mario, Valkenburg-van Iersel, Liselot, Ottesen, Lone, Li, Yan, Mugundu, Ganesh
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer Berlin Heidelberg 2020
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338825/
https://ncbi.nlm.nih.gov/pubmed/32556602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-020-04101-4
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk