Effect of food on the pharmacokinetics of the WEE1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors

PURPOSE: To support future dosing recommendations, the effect of food on the pharmacokinetics of adavosertib, a first-in-class, small-molecule reversible inhibitor of WEE1 kinase, was assessed in patients with advanced solid tumors. METHODS: In this Phase I, open-label, randomized, two-period, two-s...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Någård, Mats, Ah-See, Mei-Lin, So, Karen, Vermunt, Marit, Thistlethwaite, Fiona, Labots, Mariette, Roxburgh, Patricia, Ravaud, Alain, Campone, Mario, Valkenburg-van Iersel, Liselot, Ottesen, Lone, Li, Yan, Mugundu, Ganesh
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338825/
https://ncbi.nlm.nih.gov/pubmed/32556602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-020-04101-4
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