Wee1 Kinase Inhibitor AZD1775 Effectively Sensitizes Esophageal Cancer to Radiotherapy

PURPOSE: Esophageal cancer (ESCA) is a deadly malignancy with a 5-year survival rate of only 5–20%, which has remained unchanged for decades. ESCA possesses a high frequency of TP53 mutations leading to dysfunctional G1 cell cycle checkpoint, which likely makes ESCA cells highly reliant upon G2/M ch...

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Yang, Linlin, Shen, Changxian, Pettit, Cory, Li, Tianyun, Hu, Andrew, Miller, Eric, Zhang, Junran, Lin, Steven H., Williams, Terence M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367716/
https://ncbi.nlm.nih.gov/pubmed/32220892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-3373
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