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Dual targeting of WEE1 and PLK1 by AZD1775 elicits single agent cellular anticancer activity
Inhibition of the WEE1 tyrosine kinase enhances anticancer chemotherapy efficacy. Accordingly, the WEE1 inhibitor AZD1775 (previously MK-1775) is currently under evaluation in clinical trials for cancer in combination with chemotherapy. AZD1775 has been reported to display high selectivity and is th...
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| Publicado no: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5551971/ https://ncbi.nlm.nih.gov/pubmed/28557434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00147 |
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